Glasgow Warriors hooker Aicha Sutcliffe will make her first Scotland start in one of three changes made by interim head coach Dave Butcher for their final WXV Global Series match against Australia in Canberra on Friday.
It is the Scot's third consecutive match against the Wallaroos and they are seeking their first win in the fifth and final match across this season's competition.
Harlequins lock Sarah Bonar returns in the second row after missing the 56-12 defeat in Sydney through illness.
Meanwhile, Edinburgh's Chloe Rollie comes back into the starting line-up at full-back, with Hannah Ramsay moving to fly-half and Trailfinders' Helen Nelson to inside centre.
Sale Sharks back Evie Wills misses out, while Bristol Bears pair Lana Skeldon and Hollie Cunningham drop to the bench to make way for Sutcliffe and Bonar.
Two other Glasgow players - centre Nicole Flynn and tighthead prop Imogen Spence - are in line to make their debuts off the bench.
Scotland line-up
Chloe Rollie (Edinburgh), Rhona Lloyd (Sale Sharks), Meryl Smith (Bristol Bears), Helen Nelson (Trailfinders), Katie Buchanan (Exeter Chiefs); Hannah Ramsay (Edinburgh), Leia Brebner-Holden (Edinburgh); Anne Young (Glasgow Warriors), Aicha Sutcliffe (Glasgow Warriors), Elliann Clarke (Glasgow Warriors), Holland Bogan (Glasgow Warriors), Sarah Bonar (Harlequins), Rachel Malcolm, capt (Trailfinders), Rachel McLachlan (Montpellier), Evie Gallagher (Bristol Bears).
Replacements: Lana Skeldon (Bristol Bears), Leah Bartlett (Sale Sharks), Imogen Spence (Glasgow Warriors), Hollie Cunningham (Bristol Bears), Eva Donaldson (Sale Sharks), Ceitidh Ainsworth (Glasgow Warriors), Nicole Flynn (Glasgow Warriors) Lucia Scott (Glasgow Warriors).